Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation

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Acute kidney injury after liver transplantation is associated with viral hepatitis, prolonged warm ischemia, serum lactate and higher mortality.

We thank for the interest in our recent published article1 and the letter from Prof. Xue, et al. Our findings evidenced that viral hepatitis, warm ischemia time and serum lactate are associated with acute kidney injury (AKI) development after liver transplantation (LT). Another important finding is that AKI was associated with death and chronic kidney disease (CKD) after LT. The first concern r...

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Mycophenolate mofetil use is associated with prolonged graft survival after kidney transplantation.

BACKGROUND Mycophenolate mofetil has replaced azathioprine in many transplant centers, but data on hard outcomes such as graft and patient survival are lacking. METHODS We analyzed graft and patient survival of the 1219 first renal allograft recipients at the Medical University of Vienna who were treated with azathioprine or mycophenolate mofetil over the past decade. Cox's proportional hazar...

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PIRCHE-II Is Related to Graft Failure after Kidney Transplantation

Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibo...

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Donor Diabetes and Prolonged Cold Ischemia Time Synergistically Increase the Risk of Graft Failure After Liver Transplantation

BACKGROUND Both prolonged cold ischemia time (CIT) and donor history of diabetes mellitus (DM) are associated with reduced graft survival after liver transplantation. However, it is unknown whether the adverse effect of prolonged CIT on posttransplant graft survival is more pronounced after transplant with DM versus non-DM donor grafts. METHODS The study sample included 58 226 liver transplan...

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Association Between Prolonged Graft Ischemia and Primary Graft Failure or Survival Following Lung Transplantation.

IMPORTANCE The effect of prolonged graft ischemia (≥6 hours) on outcomes following lung transplantation is controversial. OBJECTIVE To evaluate the effect of prolonged total graft ischemia times on long-term survival rates and the development of primary graft failure (PGF) following lung transplantation. DESIGN, SETTING, AND PARTICIPANTS In this retrospective study, the United Network for O...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2016

ISSN: 0085-2538

DOI: 10.1016/j.kint.2015.09.002